How to get the gamepad working in Witcher 3? It should work according to https://github.com/lutris/lutris/wiki/Controller-support-in-Wine-games. I have set path to the-witcher-3-wild-hunt/drive_c/GOG Games/The Witcher 3 Wild Hunt/bin/x64 but it complains that “is not a valid path for x360ce” and the controller doesn’t work. The Witcher is GOG version and I installed it using lutris script.
you need lutris 0.3.14 in order to have 64bit support for x360ce + dinput8, and it’s not released yet 
you can configure it manually by copying this dll https://github.com/lutris/lutris/raw/master/share/lutris/controllers/x360ce-win64/dinput8.dll along side xinput1_3.dll
The problem you’re having seems to be something else, is your path really the-witcher-3-wild-hunt/drive_c/GOG Games/The Witcher 3 Wild Hunt/bin/x64? If so, I understand why it gets rejected, it’s not an absolute path!
I pointed the right directory from the Lutris and it should be absolute path (I can’t check it right now).
I managed to get the controller working with this https://github.com/kozec/dumbxinputemu
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dumbxinputemu looks like an interesting solution, I’m considering including it in Lutris but I have yet to test it first.