As I mentioned, I was using battle.net launcher to install and run D2R, but as I also mentioned, running D2R.exe directly had same behavior.
And yes, my lutris WoW link indeed points to battle.net.exe, otherwise I would have had real hard time installing D2R using WoW instead of bnet launcher.
But I don’t see much point in this now, as this issue is already solved.
Trying to help a friend with this here, I only run WoW so have limited ability to help - strange to need to emulate an nvidia card to get the game to run. I assume that World of Warcraft runs just fine? What Vulkan ICD loader are you using on the System Options tab? Is it set to Auto? You don’t per chance have an iGPU on your system? Also, in Wine Configuration for your WoW Lutris entry, what Windows Version is set?
Thanks for the link, we were on the Battle.net forums and like you said there are hundreds of complaints and threads on the topic, many closed. He has a i5-7500 with an rx 580 so meets the specs, but can’t get it to work on Windows 10, and was asking me if I knew how to get it working on Mint. I have helped others to install it and run it, but for him no go - I will pass this over to him to try out.