Really odd problem.
All games worked fine, not many at all just a couple of the old classic from Blizzard - StartCraft, WarCraft
Replaced old monitor with a new larger one.
On attempt to launch a game system hang, the only way to bring it back is to force turn off.
So in my case on Start a game a blizzard launcher shows up and there is a button to actually start a game, but instead a black screen, mouse & keyboard - no response.
For the sake of an experiment tried some games via Steam - launched fine.
glxgears tool works fine as well.
System is up to date.
Here is lutris issue report http://ix.io/3WwC
The game has no logs - just blank.