Neverwinter Nights tends to crash at launch if using the Mesa drivers while libtxc-dxtn-s2tc0:i386 is installed.
The good news is that it can easily be avoided, all you need to do is create an empty file named libtxc_dxtn.so in the lib/ directory that can be found at the game root directory.
I’ve not seen any feedback telling me of problems with the non-free drivers, and I put this file on any installation done via the ./play.it scripts, so I think there is no problem creating it for all users.
But I’ve not tested it on these drivers myself.