I’ve done this twice now (for science).
Install Linux Mint and update to latest stable kernel.
Install Lutris in Software manager.
Download Xenia Manager Experimental from github and extract it to home/username/.local/share/applications/xenia (2 files go here, no folder)
Launch Lutris, add installed game, select the. exe, select the xenia folder as the wine prefix and wine 9.0 as the runner.
The second I double click the icon for xenia my system locks up, even my xkill shortcut is unresponsive, and all reboots go to a login screen that works fine but then logs in to an all black system. All attempts to restore in grub and via timeshift fail and the only way to get my system operational again is a full drive wipe and reinstall of Linux Mint.
Update: Going into my os’s home folder from my installation usb and deleting the xenia folder fixed everything. Strange but I’ll take it.