I found a solution!!! to first problem. I went to wine configuration and libraries. I added dnsapi (native,builtin) ,winemenubuilder.exe (disabled) and wininet (builtin). I successfully launched the game, but it doesn’t let me login. League of legends say they can’t connect the server but i surely have the internet…
I had the same problem, uninstalled LoL, now I can’t even reinstall. I think it’s because of the newest Patch. I copied a updated Windows installation but it didn’t start with lutris. Wine 2 changed nothing.