It’s pretty much like shag00 said (I do mine a little differently, but what he said should still work).
although… I personally do have nearly all of my games using the same wine prefix though to save about 500-600MB of HDD space per wine prefix this way (so instead of roughly using 6.5-7.8GB or so (over 13 games or so) of storage space I kept it down to about 1.0-1.1GB using only two prefixes. although I am confident I could have kept it to only a single 500-600MB(0.5-0.6GB) if I wanted to). but I do have one of my games running in a separate wine prefix.
like on my system, as a example, here is pretty much how I got mine setup…
“/home/user/.RandomFolderNameHere/general” (nearly all of my games are using this)
“/home/user/.RandomFolderNameHere/GameNameHere” (one game is using this)
this way (with the DOT before ‘FolderNameHere’) that folder stays ‘hidden’ in ones file manager. that’s ‘dot’ stuff strictly optional though.
but my actual game data runs from a different hard drive though even though the wine prefix data is stored like what I listed above. but keep in mind I suggest keeping the directory structure like “/home/user/GameNameHere/” because if you try “/home/user/RandomFolderNameHere/GameNameHere/”, Lutris v0.5.13 (from May 2023, which is currently the newest version) will fail to work as it seems to have a issue creating two folders deep.
like for example…
this will fail to work… “/home/user/RandomFolderNameHere/GameNameHere/”
but if you manually create that ‘RandomFolderNameHere’ through your file manager etc in advance, then that exact same example will now work.
bottom line… if that sounds confusing, that’s why I just told you (the OP) to use “/home/user/CyberPunk/” as Lutris won’t have any issues doing that (and you can run the game data itself from any random location in your computer as I run mine from a different hard drive separate from my boot drive).
Basically you want Lutris to create it’s own wine prefix and you DO NOT want to use the system created one located at “~/.wine” (as that can cause problems as it did for me on at least two games I play until I learned basically what I typed below). so to do this…
Open Lutris, on the CyberPunk shortcut you created (I am just assuming you already got a shortcut there and it’s starting the game through the games main exe) right click it, select ‘Configure > Runner options’ and make sure something like ‘lutris-GE-Proton8-12-x86_64’ is selected. then with that same window open, now click the ‘Game options’ tab and on the ‘Wine prefix’ section type in “/home/user/CyberPunk/” (without the " and swap ‘user’ to what ever your system is setup as. this is important!!!). then click the SAVE (green in color in top right area of Lutris).
now try starting the game and see what happens is the basic idea. that’s THE first thing I would do as it should work, at least it does on my NVIDIA GPU (1050 Ti 4GB) running the NVIDIA v525 driver on Linux Mint v21.2-Xfce.