Quick debug thread to help:
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Read the pinned message on this forum - the lutris -d output is key to debugging issues. If you don’t see version 0.5.13 or newer as your lutris version, UPGRADE LUTRIS - go to the downloads area here - Ubuntu, Mint and Pop users, gdebi is best option to upgrade to the downloaded deb file, though you can try CLI to upgrade.
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If you see lutris version 0.5.13, install package vulkan-tools, then launch lutris, click on the three lines on the title bar->preferences->global options. Enable Show advanced options and scroll to the Multi-GPU section. In the Vulkan ICD Loader field, change this to an entry that matches your gpu and does not contain auto, unspecified or default.
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Again, lutris version 0.5.13 only, on the lutris main window, left hand list of icons find the runners area and click on wine. You will see a folder icon, click this and in the subsequent window make sure you have the most recent lutris-GE-Proton version installed (currently 8-12). Only install the ge-lol version if you are planning to use League of Legends.
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Remember to make sure you have all the wine dependencies (wine) and vulkan dependencies (vulkan) including the 32 bit libraries in place.