Here’s my pastebin here. I haven’t tested the animations on this current install, they were actually fixed previously, but the sound issue has persisted through multiple installs of Fallout 3 GOTY on Manjaro. It starts with the opening menu music, it is stuttering and off kilter, quite creepy sounding, actually. The animations thing happens during dialogs, the characters mouths move faster than the speech is spoken.
Thanks for any help ahead of time, if any more info is needed just let me know.
Edit/Update: I reinstalled the game with the regular installation files through Lutris rather than the modded ones and set the runner to ProtonGE 8-11 following the directions in this guide. Seems like the problems are solved!