That error tells me that the wine interpreter can’t find the wine prefix. Some variables not being set correctly or something.
A buggered up wine prefix will cause that, and system wine tricks is probably trying to operate on /home/yourname/.wine by default.
I don’t know if you actually have anything in the default ~/.wine location, but try deleting it if you don’t have games or software installed to it. It will get recreated again, “updating wine prefix in /home/yourname/.wine” if you run a system wine component.
You could also try disabling “use system winetricks” in Lutris.
I think I figured it out, it was a firejail problem, had to run sudo firecfg --clean
then I could install most of the games, now i just cant get passed that “online anti cheet” something.
and I have to figure out how to get the games to run with use of the GPU-RadeonVII but that is probably a topic of anther post.
after games where installed I could turn back on firecfg.
Been this way for years, Lutris is not helping with windows programs or games to run, you gotta do everything your self, personaly i dont use Lutris cause all the stuff you have to do without you have to do your self anyway, just another app you have on your machine with 0 use.
Had this problem with slackware, just buiilt lutris and wine from slackbuilds.
Solved by building cabextract and winetricks, delete the game you tried to install in your /home/user/Games folder or wherever you installed it, then try again.