There’s a recent update to DXVK and VK3D that breaks a lot of games under Linux. Reverting to the previous versions of DXVK and VK3D solves the issue (for me, and for a lot of people I’ve seen posting around the Internet).
In Lutris, go to Preferences, select the Runners section, scroll down to Wine, and make sure “Show advanced options” is checked. Then change “DXVK version” to v1.10.3, and “VK3D version” to v2.6.
If you have custom settings for a specific game, you may also need to right-click the game, select Configure, and make the same changes under the “Runner options” tab.
Once there’s a new update and the issue is solved, you may want to revert to the default versions, so you benefit from updates (click the little broom symbols on the right sides of the options).