I came across a Youtube video for a workaround with the memory leak on Diablo 4. Video
You just put a dxvk.conf file to limit the ammount of VRAM the game can use. I limited to 6.5 GB and running low with high textures so far without the high resolution assets for 1080p. Maybe we can come to minimum numbers for different resolutions and settings.
dxgi.maxDeviceMemory=6500
dxgi.maxSharedMemory=6500