Civilization 6 launches and runs, can't click on any buttons

Been trying to play some Civilization 6, running into an odd issue where the game seems to run just fine but doesn’t seem to accept any mouse input? No matter what buttons appear on screen, they do not respond to my mouse clicks. However, when the game is playing its intro movie, it responds to my mouse click and skips it. Haven’t had any issues running other games like Cyberpunk 2077 under Lutris nor have I had any issues running games under Steam and Proton like GTA V and BeamNG. Just having these weird issues with Civilization 6.

System Info:
Pop!_OS 22.04 LTS
AMD Ryzen 5 5600X
NVidia GeForce RTX 3070 FE
2560x1440 27in monitor (could be a weird scaling issue?)

I’ve tried changing the resolution and playing the game windowed but to no avail.