ARCH strange error while running non steam games

Hi guys.
I’m running arch linux, i have an i5 4° gen and an NVIDIA GTX 960.
I can’t run non steam games, i’ve tried many titles and the result is always the same:
i run the installer and the process of installation goes correctly, then i switch the .EXE with the installed executable but the game does not start.
If i run lutris in debug mode (lutris -d) it says that error 1280 has been found.
The game is installed on arch’s ext4 partition, dxvk is installed and works correctly with steam games, all 32bit libs are installed, i’ve generated a specific wine prefix and configured them for every game following some guides specific for the games that i’ve installed.

Did you only install games by hand, without using Lutris installers?