Currently my two tested clients are Origin and the Blizzard Launcher.
Origin Crashes at start, throws no error. The blizzard launcher prints “wine: Call from 0x7bc77779 to unimplemented function vulkan-1.dll.vkGetInstanceProcAddr, aborting” in the terminal and crashes.
Both start without problems if i deactivate DXVK.
Nvidia GTX 1060 6GB with 415.27 Driver
Vulkan/DXVK Games over Steamplay run without any problem
My system did reject the libvulkan1:i386 package somewhere along the way. I leave this here for people who may run in the same issue.